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Do not take Imitrex with any of the following medicines:

amphetamine or cocaine
dihydroergotamine, ergotamine, ergoloid mesylates, methysergide, or ergot-type medication - do not take within 24 hours of taking sumatriptan
feverfew
MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate - do not take sumatriptan within 2 weeks of stopping MAOI therapy
other migraine medicines like almotriptan, eletriptan, naratriptan, rizatriptan, zolmitriptan - do not take within 24 hours of taking sumatriptan
tryptophan

Imitrex may also interact with the following medications:

lithium
medicines for mental depression, anxiety or mood problems
medicines for weight loss such as dexfenfluramine, dextroamphetamine, fenfluramine, or sibutramine
St. John's wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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