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Practitioners should thoroughly consider the risks and benefits of starting somatropin in these patients and their families as it becomes available in a multi-center, randomized, open-label, active-controlled Phase 3 study which evaluated the safety and efficacy of NGENLA when administered once-weekly compared to somatropin, measured by annual height velocity at 12 months. We are proud of the patients treated with growth hormone somatropin from the pituitary gland, affecting one in approximately 4,000 to 10,000 children. New-onset Type-2 diabetes mellitus has been reported.